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coagulation factor V

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Target id: 2606

Nomenclature: coagulation factor V

Family: Blood coagulation components

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2224 1q24.2 F5 coagulation factor V
Mouse - 2183 1 71.46 cM F5 coagulation factor V
Rat - 1942 13q22 F5 coagulation factor V
Previous and Unofficial Names Click here for help
coagulation factor V (proaccelerin, labile factor)
Database Links Click here for help
Alphafold P12259 (Hs), O88783 (Mm)
CATH/Gene3D 2.60.120.260, 2.60.40.420
ChEMBL Target CHEMBL3618 (Hs)
DrugBank Target P12259 (Hs)
Ensembl Gene ENSG00000198734 (Hs), ENSMUSG00000026579 (Mm), ENSRNOG00000057855 (Rn)
Entrez Gene 2153 (Hs), 14067 (Mm), 304929 (Rn)
Human Protein Atlas ENSG00000198734 (Hs)
KEGG Gene hsa:2153 (Hs), mmu:14067 (Mm), rno:304929 (Rn)
OMIM 612309 (Hs)
Orphanet ORPHA121673 (Hs)
Pharos P12259 (Hs)
RefSeq Nucleotide NM_000130 (Hs), NM_007976 (Mm), NM_001047878 (Rn)
RefSeq Protein NP_000121 (Hs), NP_032002 (Mm)
UniProtKB P12259 (Hs), O88783 (Mm)
Wikipedia F5 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the C2 domain of human coagulation factor V
PDB Id:  1CZT
Resolution:  1.87Å
Species:  Human
References:  3

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
drotrecogin alfa Peptide Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition - - 1-2
⤷ Antithrombotic effect thought to occur via inhibition of factors Va and VIIIa [1-2]
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
F2rtm1Ajc|F5tm1Dgi F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
B6.Cg-F5 F2r		 MGI:101802  MGI:88382  MP:0001698 decreased embryo size PMID: 11533492 
F2rtm1Ajc|F5tm1Dgi F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
B6.Cg-F5 F2r		 MGI:101802  MGI:88382  MP:0006207 embryonic lethality during organogenesis PMID: 11533492 
F2rtm1Ajc|F5tm1Dgi F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
B6.Cg-F5 F2r		 MGI:101802  MGI:88382  MP:0005244 hemopericardium PMID: 11533492 
F2rtm1Ajc|F5tm1Dgi F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
B6.Cg-F5 F2r		 MGI:101802  MGI:88382  MP:0001914 hemorrhage PMID: 11533492 
F2rtm1Ajc|F5tm1Dgi F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
B6.Cg-F5 F2r		 MGI:101802  MGI:88382  MP:0005312 pericardial effusion PMID: 11533492 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Budd-Chiari syndrome
OMIM: 600880
Orphanet: ORPHA131
Disease:  Cerebral sinovenous thrombosis
Orphanet: ORPHA329217
Disease:  Factor V deficiency
Disease Ontology: DOID:2216
OMIM: 227400
Orphanet: ORPHA326
Disease:  Pregnancy loss, recurrent, susceptibility to, 1
OMIM: 614389
Disease:  Stroke, ischemic
Synonyms: Cerebral infarction
Cerebrovascular accident [Disease Ontology: DOID:3455]
Disease Ontology: DOID:3455
OMIM: 601367
Disease:  Thrombophilia due to activated protein C resistance
Synonyms: Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 188055

References

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1. Kanji S, Devlin JW, Piekos KA, Racine E. (2001) Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis. Pharmacotherapy, 21 (11): 1389-402. [PMID:11714212]

2. Kapur S, Kupfer Y, Tessler S. (2001) Recombinant human activated protein C for severe sepsis. N Engl J Med, 345 (3): 219-20; author reply 220-1. [PMID:11463021]

3. Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH et al.. (1999) Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature, 402 (6760): 434-9. [PMID:10586886]

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