Gene and Protein Information
class C G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	441	17q25.1	GPRC5C	G protein-coupled receptor class C group 5 member C	2
Mouse	7	440	11 E2	Gprc5c	G protein-coupled receptor, family C, group 5, member C
Rat	7	441	10q32.1	Gprc5c	G protein-coupled receptor, class C, group 5, member C

Previous and Unofficial Names

RAIG3 | retinoic acid-induced gene 3 protein | G protein-coupled receptor, family C, group 5, member C | G protein-coupled receptor, class C, group 5, member C | G protein-coupled receptor

Database Links
Alphafold	Q9NQ84 (Hs), Q8K3J9 (Mm), Q3KRC4 (Rn)
ChEMBL Target	CHEMBL4523921 (Hs)
Ensembl Gene	ENSG00000170412 (Hs), ENSMUSG00000051043 (Mm), ENSRNOG00000003144 (Rn)
Entrez Gene	55890 (Hs), 70355 (Mm), 287805 (Rn)
Human Protein Atlas	ENSG00000170412 (Hs)
KEGG Gene	hsa:55890 (Hs), mmu:70355 (Mm), rno:287805 (Rn)
OMIM	605949 (Hs)
Pharos	Q9NQ84 (Hs)
RefSeq Nucleotide	NM_018653 (Hs), NM_147217 (Mm), NM_001191591
RefSeq Protein	NP_061123 (Hs), NP_671750 (Mm), NP_001178520 (Rn)
UniProtKB	Q9NQ84 (Hs), Q8K3J9 (Mm), Q3KRC4 (Rn)
Wikipedia	GPRC5C (Hs)

Tissue Distribution
Highest expression in adult cerebellum, spinal cord, liver, lung, kidney, pancreas, spleen, stomach and prostate. Species:  Human Technique:  RT-PCR References:  2
High expression in adult kidney, pancreas and prostate. Medium expression in adult liver and spleen. Low expression in colon, small intestine and testis. Not detectable in brain, heart, lung, placenta, skeletal muscle, ovary, leukocyte and thymus. Species:  Human Technique:  RT-PCR References:  1

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

General Comments
Orphan receptor. mRNA expression is induced by retinoic acid in some cell lines. Hyaluronic acid in the extracellular matrix of the bone marrow is reported to promote haematopoietic stem cell dormancy via interaction with GPRC5C [3]