Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1076	19q13.2	LIPE	lipase E, hormone sensitive type
Mouse	-	759	7 13.78 cM	Lipe	lipase, hormone sensitive
Rat	-	1068	1q21	Lipe	lipase E, hormone sensitive type

Previous and Unofficial Names

HSL | lipase, hormone-sensitive | lipase, hormone sensitive | lipase E | lipase

Database Links
Specialist databases
MEROPS	S09.993 (Hs)
Other databases
Alphafold	Q05469 (Hs), P54310 (Mm), P15304 (Rn)
BRENDA	3.1.1.79
CATH/Gene3D	3.40.50.1820
ChEMBL Target	CHEMBL3590 (Hs), CHEMBL5935 (Mm), CHEMBL5582 (Rn)
Ensembl Gene	ENSG00000079435 (Hs), ENSMUSG00000003123 (Mm), ENSRNOG00000020546 (Rn)
Entrez Gene	3991 (Hs), 16890 (Mm), 25330 (Rn)
Human Protein Atlas	ENSG00000079435 (Hs)
KEGG Enzyme	3.1.1.79
KEGG Gene	hsa:3991 (Hs), mmu:16890 (Mm), rno:25330 (Rn)
OMIM	151750 (Hs)
Pharos	Q05469 (Hs)
RefSeq Nucleotide	NM_005357 (Hs), NM_010719 (Mm), NM_012859 (Rn)
RefSeq Protein	NP_005348 (Hs), NP_034849 (Mm), NP_036991 (Rn)
UniProtKB	Q05469 (Hs), P54310 (Mm), P15304 (Rn)
Wikipedia	LIPE (Hs)

Enzyme Reaction
EC Number: 3.1.1.79

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 41 [PMID: 15026062] Hs Inhibition 9.0 pIC50 1 ⤷ pIC50 9.0 (IC50 1x10-9 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Lipodystrophy, familial partial, type 6; FPLD6 Synonyms: Familial partial lipodystrophy [Disease Ontology: DOID:0050440] Disease Ontology: DOID:0050440 OMIM: 615980