Top ▲

GPRC5B

Click here for help

Target id: 259

Nomenclature: GPRC5B

Family: Class C Orphans

Gene and Protein Information Click here for help
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 403 16p12.3 GPRC5B G protein-coupled receptor class C group 5 member B 1,4
Mouse 7 410 7 F2 Gprc5b G protein-coupled receptor, family C, group 5, member B 3
Rat 7 394 1q35 Gprc5b G protein-coupled receptor, class C, group 5, member B
Previous and Unofficial Names Click here for help
RAIG2 | retinoic acid-induced gene 2 protein | G protein-coupled receptor, class C, group 5, member B | G protein-coupled receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050729 positive regulation of inflammatory response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0050729 positive regulation of inflammatory response ISS
GO:0060907 positive regulation of macrophage cytokine production ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0060907 positive regulation of macrophage cytokine production ISS
Tissue Distribution Click here for help
High expression in adult kidney, pancreas and testis.
Medium expression in adult brain, heart, prostate, small intestine and spleen.
Low expression in adult liver, placenta, skeletal muscle, colon, ovary and thymus.
Not detectable in adult lung and peripheral leukocyte.
Species:  Human
Technique:  RT-PCR
References:  2
High expression in adult brain and spinal cord.
Medium to low expression in adult pancreas, testis, uterus and stomach.
Species:  Human
Technique:  RT-PCR
References:  4
Expression Datasets Click here for help

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
General Comments
Orphan receptor.
mRNA expression is induced by retinoic acid in some cell lines.

References

Show »

1. Bräuner-Osborne H, Krogsgaard-Larsen P. (2000) Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics, 65 (2): 121-8. [PMID:10783259]

2. Cheng Y, Lotan R. (1998) Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J Biol Chem, 273: 35008-35015. [PMID:9446598]

3. Inoue S, Sano H, Ohta M. (2000) Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Biochem Biophys Res Commun, 268: 553-561. [PMID:10679242]

4. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. (2000) Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics, 67 (1): 8-18. [PMID:10945465]

Contributors

Show »

How to cite this page