Gene and Protein Information
class A G protein-coupled receptor: pseudogene in man
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	5	292	1q21.1	GNRHR2	gonadotropin releasing hormone receptor 2 (pseudogene)

Previous and Unofficial Names

Type II GnRHR | gonadotropin-releasing hormone (type 2) receptor 2 | gonadotropin-releasing hormone (type 2) receptor 2, pseudogene

Database Links
Alphafold	Q96P88 (Hs)
DrugBank Target	Q96P88 (Hs)
Ensembl Gene	ENSG00000211451 (Hs)
Entrez Gene	114814 (Hs)
Human Protein Atlas	ENSG00000211451 (Hs)
KEGG Gene	hsa:114814 (Hs)
OMIM	612875 (Hs)
Pharos	Q96P88 (Hs)
RefSeq Nucleotide	NR_002328 (Hs)
UniProtKB	Q96P88 (Hs)
Wikipedia	GNRHR2 (Hs)

Natural/Endogenous Ligands
GnRH I {Sp: Human, Mouse, Rat}
GnRH II {Sp: Human}
Comments: Probable transcribed pseudogene in man [3]. Natural/endogenous ligands refer to non-human mammalian species.

Potency order of endogenous ligands (Human)

GnRH II (GNRH2, O43555) > GnRH I (GNRH1, P01148)  [2]

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference GnRH II {Sp: Human} Monkey Full agonist 9.0 pIC50 2 ⤷ pIC50 9.0 (IC50 1.07x10-9 M) [2] GnRH I {Sp: Human, Mouse, Rat} Monkey Full agonist 7.4 pIC50 2-3 ⤷ pIC50 7.4 (IC50 4.26x10-8 M) [2-3]

Antagonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference trptorelix-1 Monkey Antagonist - - 1 ⤷ [1]

Primary Transduction Mechanisms
Transducer	Effector/Response
Gq/G11 family	Phospholipase C stimulation
References:  3