Top ▲

GnRH2 receptor

Click here for help

Target id: 257

Nomenclature: GnRH2 receptor

Family: Gonadotrophin-releasing hormone receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor: pseudogene in man
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 5 292 1q21.1 GNRHR2 gonadotropin releasing hormone receptor 2 (pseudogene)
Previous and Unofficial Names Click here for help
Type II GnRHR | gonadotropin-releasing hormone (type 2) receptor 2 | gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
Database Links Click here for help
Alphafold
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
GnRH I {Sp: Human, Mouse, Rat}
GnRH II {Sp: Human}
Comments: Probable transcribed pseudogene in man [3]. Natural/endogenous ligands refer to non-human mammalian species.
Potency order of endogenous ligands (Human)
GnRH II (GNRH2, O43555) > GnRH I (GNRH1, P01148)  [2]

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GnRH II {Sp: Human} Peptide Monkey Full agonist 9.0 pIC50 2
pIC50 9.0 (IC50 1.07x10-9 M) [2]
GnRH I {Sp: Human, Mouse, Rat} Peptide Monkey Full agonist 7.4 pIC50 2-3
pIC50 7.4 (IC50 4.26x10-8 M) [2-3]
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
trptorelix-1 Peptide Monkey Antagonist - - 1
[1]
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  3

References

Show »

1. Maiti K, Li JH, Wang AF, Acharjee S, Kim WP, Im WB, Kwon HB, Seong JY. (2003) GnRH-II analogs for selective activation and inhibition of non-mammalian and type-II mammalian GnRH receptors. Mol Cells, 16 (2): 173-9. [PMID:14651258]

2. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R et al.. (2001) A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc Natl Acad Sci USA, 98 (17): 9636-41. [PMID:11493674]

3. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. (2004) Gonadotropin-releasing hormone receptors. Endocr Rev, 25 (2): 235-75. [PMID:15082521]

Contributors

Show »

How to cite this page