serine palmitoyltransferase long chain base subunit 1 | Serine palmitoyltransferase | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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serine palmitoyltransferase long chain base subunit 1

Target id: 2509

Nomenclature: serine palmitoyltransferase long chain base subunit 1

Abbreviated Name: SPT1

Family: Serine palmitoyltransferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 473 9q22.31 SPTLC1 serine palmitoyltransferase long chain base subunit 1
Mouse - 473 13 B1 Sptlc1 serine palmitoyltransferase
Rat - 473 17p14 Sptlc1 serine palmitoyltransferase
Previous and Unofficial Names
hereditary sensory neuropathy, type 1 | HSN1 | LCB1 | Serine-palmitoyl-CoA transferase 1 | SPTI | serine palmitoyltransferase, long chain base subunit 1 | serine palmitoyltransferase
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
Cofactor Species Comments Reference
pyridoxal 5-phosphate Human

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
myriocin Mm Inhibition 9.6 pKi 1
pKi 9.6 (Ki 2.8x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Neuropathy, hereditary sensory and autonomic, type IA; HSAN1A
Synonyms: Hereditary sensory and autonomic neuropathy [Disease Ontology: DOID:11533]
Hereditary sensory and autonomic neuropathy type 1 [Orphanet: ORPHA36386]
Disease Ontology: DOID:11533
OMIM: 162400
Orphanet: ORPHA36386


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1. Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun., 211 (2): 396-403. [PMID:7794249]

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