Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	264	19p13.3	ACER1	alkaline ceramidase 1
Mouse	7	273	17 D	Acer1	alkaline ceramidase 1
Rat	-	273	9q11	Acer1	alkaline ceramidase 1

Previous and Unofficial Names

Acylsphingosine deacylase 3 | Alkaline CDase 1 | AlkCDase 1 | ASAH3 | Cer1

Database Links
Alphafold	Q8TDN7 (Hs), Q8R4X1 (Mm)
BRENDA	3.5.1.23
ChEMBL Target	CHEMBL3351194 (Hs)
Ensembl Gene	ENSG00000167769 (Hs), ENSMUSG00000045019 (Mm), ENSRNOG00000047368 (Rn)
Entrez Gene	125981 (Hs), 171168 (Mm), 301118 (Rn)
Human Protein Atlas	ENSG00000167769 (Hs)
KEGG Enzyme	3.5.1.23
KEGG Gene	hsa:125981 (Hs), mmu:171168 (Mm), rno:301118 (Rn)
OMIM	613491 (Hs)
Pharos	Q8TDN7 (Hs)
RefSeq Nucleotide	NM_133492 (Hs), NM_175731 (Mm), NM_001106875 (Rn)
RefSeq Protein	NP_597999 (Hs), NP_783858 (Mm), NP_001100345 (Rn)
UniProtKB	Q8TDN7 (Hs), Q8R4X1 (Mm)
Wikipedia	ACER1 (Hs)

Enzyme Reaction
EC Number: 3.5.1.23 ceramide -> sphingosine + a fatty acid

Immunopharmacology Comments

The major biological role of ACER1 is that of maintaining skin homeostasis via regulation of keratinocyte differentiation [1]. ACER1 is included in GtoImmuPdb because of its involvement in generating the sphingolipid sphingosine, which is subsequently phosphorylated (by sphingosine kinase) to the bioactive lipid mediator S1P [3]. S1P is a major regulator of the vascular and immune systems. In the immune system S1P activation of its receptor S1P1R promotes trafficking of T and B cells from the lymphoid organs into the lymphatic vessels.

Tissue Distribution
Human epidermal keratinocytes Species:  Human Technique:  In situ hybridization, RT-PCR. References:  2