acetyl-CoA acetyltransferase 2 | Lanosterol biosynthesis pathway | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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acetyl-CoA acetyltransferase 2

Target id: 2436

Nomenclature: acetyl-CoA acetyltransferase 2

Family: Lanosterol biosynthesis pathway

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 397 6q25.3-q26 ACAT2 acetyl-CoA acetyltransferase 2 2
Mouse - 397 17 A2-A3 Acat2 acetyl-Coenzyme A acetyltransferase 2
Rat - 397 1q11 Acat2 acetyl-CoA acetyltransferase 2
Previous and Unofficial Names
Acat3 | Acetyl-CoA acetyltransferase, cytosolic | Cytosolic acetoacetyl-CoA thiolase | acetoacetyl Coenzyme A thiolase | acetyl-Coenzyme A acetyltransferase 3
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 2acetyl CoA = acetoacetyl CoA + coenzyme A

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
K-604 Hs Inhibition 3.9 pIC50 1
pIC50 3.9 (IC50 1.3x10-4 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Acetyl-CoA acetyltransferase-2 deficiency; ACAT2D
OMIM: 614055


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1. Ikenoya M, Yoshinaka Y, Kobayashi H, Kawamine K, Shibuya K, Sato F, Sawanobori K, Watanabe T, Miyazaki A. (2007) A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis, 191 (2): 290-7. [PMID:16820149]

2. Masuno M, Fukao T, Song XQ, Yamaguchi S, Orii T, Kondo N, Imaizumi K, Kuroki Y. (1996) Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. Genomics, 36 (1): 217-8. [PMID:8812443]


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