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tripeptidyl peptidase 2

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Target id: 2423

Nomenclature: tripeptidyl peptidase 2

Family: S8: Subtilisin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1249 13q33.1 TPP2 tripeptidyl peptidase 2
Mouse - 1262 1 23.5 cM Tpp2 tripeptidyl peptidase II
Rat - 1249 9q22 Tpp2 tripeptidyl peptidase 2
Previous and Unofficial Names Click here for help
TppII | tripeptidyl aminopeptidase
Database Links Click here for help
Specialist databases
MEROPS S08.090 (Hs)
Other databases
Alphafold P29144 (Hs), Q64514 (Mm), Q64560 (Rn)
BRENDA 3.4.14.10
CATH/Gene3D 3.40.50.200
ChEMBL Target CHEMBL6156 (Hs), CHEMBL5512 (Mm), CHEMBL4675 (Rn)
Ensembl Gene ENSG00000134900 (Hs), ENSMUSG00000041763 (Mm), ENSRNOG00000011194 (Rn)
Entrez Gene 7174 (Hs), 22019 (Mm), 81815 (Rn)
Human Protein Atlas ENSG00000134900 (Hs)
KEGG Enzyme 3.4.14.10
KEGG Gene hsa:7174 (Hs), mmu:22019 (Mm), rno:81815 (Rn)
OMIM 190470 (Hs)
Pharos P29144 (Hs)
RefSeq Nucleotide NM_003291 (Hs), NM_009418 (Mm), NM_031137 (Rn)
RefSeq Protein NP_003282 (Hs), NP_033444 (Mm), NP_112399 (Rn)
UniProtKB P29144 (Hs), Q64514 (Mm), Q64560 (Rn)
Wikipedia TPP2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.14.10

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
example 8 [WO1999033801A1] Small molecule or natural product Hs Inhibition 9.4 pKi 1
⤷ pKi 9.4 (Ki 3.6x10-10 M) [1]
peptide 4 [PMID: 18294843] Small molecule or natural product Hs Inhibition 7.7 pKi 2
⤷ pKi 7.7 (Ki 2x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Cellular signalling

References

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1. Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. (1999) Tripeptidyl peptidase inhibitors. Patent number: WO1999033801 A1. Assignee: Inst Nat Sante Rech Med, Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. Priority date: 23/12/1998. Publication date: 08/07/1999.

2. Levengood MR, van der Donk WA. (2008) Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett, 18 (10): 3025-8. [PMID:18294843]

How to cite this page

S8: Subtilisin: tripeptidyl peptidase 2. Last modified on 16/07/2015. Accessed on 27/03/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2423.