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legumain

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Target id: 2380

Nomenclature: legumain

Family: C13: Legumain

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 433 14q32.12 LGMN legumain
Mouse - 435 12 E Lgmn legumain
Rat - 435 6q32 Lgmn legumain
Previous and Unofficial Names Click here for help
AEP1 | asparagine endo peptidase | asparagine endopeptidase | asparaginyl endopeptidase 1 | LGMN1 | protease, cysteine 1 | Prsc1
Database Links Click here for help
Specialist databases
MEROPS C13.004 (Hs)
Other databases
Alphafold Q99538 (Hs), O89017 (Mm), Q9R0J8 (Rn)
BRENDA 3.4.22.34
ChEMBL Target CHEMBL4244 (Hs), CHEMBL1949492 (Mm)
Ensembl Gene ENSG00000100600 (Hs), ENSMUSG00000021190 (Mm), ENSRNOG00000007089 (Rn)
Entrez Gene 5641 (Hs), 19141 (Mm), 63865 (Rn)
Human Protein Atlas ENSG00000100600 (Hs)
KEGG Enzyme 3.4.22.34
KEGG Gene hsa:5641 (Hs), mmu:19141 (Mm), rno:63865 (Rn)
OMIM 602620 (Hs)
Pharos Q99538 (Hs)
RefSeq Nucleotide NM_005606 (Hs), NM_001008530 (Hs), NM_011175 (Mm), NM_022226 (Rn)
RefSeq Protein NP_001008530 (Hs), NP_005597 (Hs), NP_035305 (Mm), NP_071562 (Rn)
UniProtKB Q99538 (Hs), O89017 (Mm), Q9R0J8 (Rn)
Wikipedia LGMN (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.22.34

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7u [PMID: 24775305] Small molecule or natural product Primary target of this compound Hs Inhibition 9.1 pIC50 1
⤷ pIC50 9.1 (IC50 9x10-10 M) [1]
compound 18 [PMID: 38090813] Small molecule or natural product Hs Inhibition 8.1 pIC50 2
⤷ pIC50 8.1 (IC50 7.8x10-9 M) [2]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0090026 positive regulation of monocyte chemotaxis IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0090026 positive regulation of monocyte chemotaxis IDA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0090026 positive regulation of monocyte chemotaxis IDA

References

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1. Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P et al.. (2014) P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett, 24 (11): 2521-4. [PMID:24775305]

2. Krummenacher D, He W, Kuhn B, Schnider C, Beurier A, Brom V, Sivasothy T, Marty C, Tosstorff A, Hewings DS et al.. (2023) Discovery of Orally Available and Brain Penetrant AEP Inhibitors. J Med Chem, 66 (24): 17026-17043. [PMID:38090813]

How to cite this page

C13: Legumain: legumain. Last modified on 22/01/2024. Accessed on 30/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2380.