Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	729	3p21.1	BAP1	BRCA1 associated protein 1
Mouse	-	728	14 B	Bap1	Brca1 associated protein 1
Rat	-	727	16p16	Bap1	Brca1 associated protein 1

Previous and Unofficial Names

ubiquitin C-terminal hydrolase X4 | UCHL2 | uch-x4 | hucep-6 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

Database Links
Specialist databases
MEROPS	C12.004 (Hs)
Other databases
Alphafold	Q92560 (Hs), Q99PU7 (Mm), D3ZHS6 (Rn)
BRENDA	3.4.19.12
CATH/Gene3D	3.40.532.10
ChEMBL Target	CHEMBL1293314 (Hs)
Ensembl Gene	ENSG00000163930 (Hs), ENSMUSG00000021901 (Mm), ENSRNOG00000019097 (Rn)
Entrez Gene	8314 (Hs), 104416 (Mm), 306257 (Rn)
Human Protein Atlas	ENSG00000163930 (Hs)
KEGG Enzyme	3.4.19.12
KEGG Gene	hsa:8314 (Hs), mmu:104416 (Mm), rno:306257 (Rn)
OMIM	603089 (Hs)
Orphanet	ORPHA289543 (Hs)
Pharos	Q92560 (Hs)
RefSeq Nucleotide	NM_004656 (Hs), NM_027088 (Mm), NM_001107292 (Rn)
RefSeq Protein	NP_004647 (Hs), NP_081364 (Mm), NP_001100762 (Rn)
UniProtKB	Q92560 (Hs), Q99PU7 (Mm), D3ZHS6 (Rn)
Wikipedia	BAP1 (Hs)

Enzyme Reaction
EC Number: 3.4.19.12

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 2 GO processes, IEA only click arrow to show/hide IEA associations GO:0050727 regulation of inflammatory response IEA GO:1900015 regulation of cytokine production involved in inflammatory response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 5 GO processes, IEA only click arrow to show/hide IEA associations GO:0043249 erythrocyte maturation IEA GO:0043363 nucleate erythrocyte differentiation IEA GO:0050727 regulation of inflammatory response IEA GO:0061519 macrophage homeostasis IEA GO:1900015 regulation of cytokine production involved in inflammatory response IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:1900015 regulation of cytokine production involved in inflammatory response IEA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Malignant mesothelioma Disease Ontology: DOID:1790 OMIM: 156240
Disease:  Tumor predisposition syndrome Synonyms: BAP1-related tumor predisposition syndrome [Orphanet: ORPHA289539] OMIM: 614327 Orphanet: ORPHA289539