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Interleukin-1 receptor, type II

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Target id: 2321

Nomenclature: Interleukin-1 receptor, type II

Family: Immunoglobulin-like family of IL-1 receptors

Quaternary Structure: Subunits
Interleukin 1 receptor, type II (Ligand-binding subunit)
IL-1 receptor accessory protein (Other subunit)
Immunopharmacology Comments
Interleukin-1 receptor, type II (IL-1RII) is a heterodimer containing the ligand binding interleukin 1 receptor, type II (IL1R2) subunit and the IL-1 receptor accessory protein (IL1RAP). Unlike IL-1RI, IL-1RII is unable to transduce a signal in response to ligand binding, acting instead as a decoy receptor for its ligands IL-1α, IL-1β.

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor, type II. Last modified on 21/03/2017. Accessed on 21/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY,