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WEE2 oocyte meiosis inhibiting kinase

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Target id: 2279

Nomenclature: WEE2 oocyte meiosis inhibiting kinase

Abbreviated Name: WEE1B

Family: WEE family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 567 7q34 WEE2 WEE2 oocyte meiosis inhibiting kinase
Mouse - 555 6 B1 Wee2 WEE1 homolog 2 (S. pombe)
Rat - - 4q22 Wee2 WEE2 oocyte meiosis inhibiting kinase
Previous and Unofficial Names Click here for help
WEE1 homolog 2 | wee1-like protein kinase 2
Database Links Click here for help
Alphafold P0C1S8 (Hs), Q66JT0 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5095 (Hs)
Ensembl Gene ENSG00000214102 (Hs), ENSMUSG00000037159 (Mm), ENSRNOG00000026446 (Rn)
Entrez Gene 494551 (Hs), 381759 (Mm), 502750 (Rn)
Human Protein Atlas ENSG00000214102 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:494551 (Hs), mmu:381759 (Mm), rno:502750 (Rn)
OMIM 614084 (Hs)
Pharos P0C1S8 (Hs)
RefSeq Nucleotide NM_001105558 (Hs), NM_201370 (Mm)
RefSeq Protein NP_001099028 (Hs), NP_958758 (Mm)
UniProtKB P0C1S8 (Hs), Q66JT0 (Mm)
Wikipedia WEE2 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: WEE2
Ligand Sp. Type Action Value Parameter
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.2 pKd
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.0 pKd
dasatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
neratinib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 5.9 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
masitinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

WEE family: WEE2 oocyte meiosis inhibiting kinase. Last modified on 12/11/2019. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2279.