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TATA-box binding protein associated factor 1

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Target id: 2231

Nomenclature: TATA-box binding protein associated factor 1

Abbreviated Name: TAF1

Family: TAF1 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1872 Xq13.1 TAF1 TATA-box binding protein associated factor 1
Mouse - 1891 X 44.29 cM Taf1 TATA-box binding protein associated factor 1
Rat - 1893 X q31 Taf1 TATA-box binding protein associated factor 1
Previous and Unofficial Names Click here for help
Ccg1 | dystonia 3 (with Parkinsonism) | DYT3/TAF1 | KAT4 | TAF2A, BA2R, CCG1, CCGS, DYT3 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF1 RNA polymerase II
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the tandem bromodomains of human transcription initiation factor TFIID subunit 1 (TAF1).
PDB Id:  3UV5
Resolution:  2.03Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number:

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Ligand Sp. Action Value Parameter Reference
BAY-299 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.9 pIC50 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]
Description: In a BROMOscan® assay.
Immuno Process Associations
Immuno Process:  Cellular signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Dystonia 3, torsion, X-linked; DYT3
Synonyms: X-linked dystonia-parkinsonism [Orphanet: ORPHA53351]
OMIM: 314250
Orphanet: ORPHA53351
General Comments
TAF1 is a component of the STAGA complex, which contains TRRAP, GCN5, TFIID, CBP/P300 and Sp1. TAF1 is susceptible to oncogenic activation by MYC and has been shown to block p53 activity. Inactivation of TAF1 triggers a DNA damage response. BAY-299 is an inhibitor of TAF1 that can be used to further characterise its biological role and may also provide a lead for future development for anti-proliferative potential.


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1. Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T et al.. (2012) Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149 (1): 214-31. [PMID:22464331]

2. SGC. BAY-299 A probe for BRD1 and TAF1. Accessed on 05/04/2017. Modified on 04/08/2023. SGC,

How to cite this page

TAF1 family: TATA-box binding protein associated factor 1. Last modified on 05/04/2017. Accessed on 23/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,