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GPR179

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Target id: 211

Nomenclature: GPR179

Family: Class C Orphans

Gene and Protein Information Click here for help
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 2367 17q12 GPR179 G protein-coupled receptor 179
Mouse 7 2293 11 D Gpr179 G protein-coupled receptor 179
Rat 7 2309 10q31 Gpr179 G protein-coupled receptor 179
Previous and Unofficial Names Click here for help
GPR158-like 1
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin
PDB Id:  8D1B
Resolution:  3.57Å
Species:  Human
References:  1
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution Click here for help
Full length cDNA (AY584611) from pituitary, unigene ESTs from heart, brain and eye.
Species:  Human
Technique: 
References: 
ESTs from pituitary, hypothalamus and brain.
Species:  Mouse
Technique: 
References: 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Night blindness, congenital stationary, type 1E; CSNB1E
Synonyms: Congenital stationary night blindness [Orphanet: ORPHA215] [Disease Ontology: DOID:0050534]
Disease Ontology: DOID:0050534
OMIM: 614565
Orphanet: ORPHA215
References:  2
General Comments
Protein sequence similar to GPR158 but with much larger carboxyl terminal intracellular domain. 44% amino acid identity between human GPR158 and GPR179 excluding the carboxyl terminal domain.

References

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1. Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR et al.. (2023) Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179. Sci Signal, 16 (795): eadd9539. [PMID:37490546]

2. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM et al.. (2012) GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet, 90 (2): 331-9. [PMID:22325362]

Contributors

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