Gene and Protein Information
class C G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	2367	17q12	GPR179	G protein-coupled receptor 179
Mouse	7	2293	11 D	Gpr179	G protein-coupled receptor 179
Rat	7	2309	10q31	Gpr179	G protein-coupled receptor 179

Previous and Unofficial Names

GPR158-like 1

Database Links
Alphafold	Q6PRD1 (Hs)
Ensembl Gene	ENSG00000277399 (Hs), ENSMUSG00000070337 (Mm), ENSRNOG00000029245 (Rn)
Entrez Gene	440435 (Hs), 217143 (Mm), 287657 (Rn)
Human Protein Atlas	ENSG00000277399 (Hs)
KEGG Gene	hsa:440435 (Hs), mmu:217143 (Mm), rno:287657 (Rn)
OMIM	614515 (Hs)
Orphanet	ORPHA292381 (Hs)
Pharos	Q6PRD1 (Hs)
RefSeq Nucleotide	NM_001004334 (Hs), NM_001081220 (Mm)
RefSeq Protein	NP_001004334 (Hs), NP_001074689 (Mm)
UniProtKB	Q6PRD1 (Hs)
Wikipedia	GPR179 (Hs)

Selected 3D Structures
	Description:  CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin PDB Id:  8D1B Resolution:  3.57Å Species:  Human References:  1

Agonist Comments

No ligands identified: orphan receptor.

Tissue Distribution
Full length cDNA (AY584611) from pituitary, unigene ESTs from heart, brain and eye. Species:  Human Technique:  References:
ESTs from pituitary, hypothalamus and brain. Species:  Mouse Technique:  References:

Clinically-Relevant Mutations and Pathophysiology
Disease:  Night blindness, congenital stationary, type 1E; CSNB1E Synonyms: Congenital stationary night blindness [Orphanet: ORPHA215] [Disease Ontology: DOID:0050534] Disease Ontology: DOID:0050534 OMIM: 614565 Orphanet: ORPHA215 References:  2

General Comments
Protein sequence similar to GPR158 but with much larger carboxyl terminal intracellular domain. 44% amino acid identity between human GPR158 and GPR179 excluding the carboxyl terminal domain.