Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	401	8q24.12	TNFRSF11B	TNF receptor superfamily member 11b
Mouse	-	401	15 D1	Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Rat	-	401	7q32	Tnfrsf11b	TNF receptor superfamily member 11B

Previous and Unofficial Names

osteoclastogenesis inhibitory factor | TR1 | tumor necrosis factor receptor superfamily, member 11b | tumor necrosis factor receptor superfamily member 11b | tumor necrosis factor receptor superfamily

Database Links
Alphafold	O00300 (Hs), O08712 (Mm), O08727 (Rn)
Ensembl Gene	ENSG00000164761 (Hs), ENSMUSG00000063727 (Mm), ENSRNOG00000008336 (Rn)
Entrez Gene	4982 (Hs), 18383 (Mm), 25341 (Rn)
Human Protein Atlas	ENSG00000164761 (Hs)
KEGG Gene	hsa:4982 (Hs), mmu:18383 (Mm), rno:25341 (Rn)
OMIM	602643 (Hs)
Pharos	O00300 (Hs)
UniProtKB	O00300 (Hs), O08712 (Mm), O08727 (Rn)
Wikipedia	TNFRSF11B (Hs)

Immunopharmacology Comments

The protein product of the TNFRSF11B gene, osteoprotegerin, acts as a soluble decoy receptor for RANK ligand (RANKL) and for TRAIL. Experimental evidence links the RANK/RANKL signalling pathway with the inflammatory activation of microglial cells relevant in the development of infection-induced perinatal brain injury [1], and as an inhibitory factor in the inflammation underlying coronary artery atherosclerotic plaque formation [2].

Immuno Process Associations

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0045671 negative regulation of osteoclast differentiation ISO

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0045671 negative regulation of osteoclast differentiation ISO