Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	260	12p13.31	CD27	CD27 molecule
Mouse	1	250	6 59.32 cM	Cd27	CD27 antigen
Rat	-	-		Cd27	CD27 molecule

Previous and Unofficial Names

CD antigen 27 | CD27 molecule | Tp55

Database Links
Alphafold	P26842 (Hs), P41272 (Mm)
ChEMBL Target	CHEMBL3713333 (Hs)
Ensembl Gene	ENSG00000139193 (Hs), ENSMUSG00000030336 (Mm), ENSRNOG00000027466 (Rn)
Entrez Gene	939 (Hs), 21940 (Mm), 500318 (Rn)
Human Protein Atlas	ENSG00000139193 (Hs)
KEGG Gene	hsa:939 (Hs), mmu:21940 (Mm), rno:500318 (Rn)
OMIM	186711 (Hs)
Pharos	P26842 (Hs)
UniProtKB	P26842 (Hs), P41272 (Mm)
Wikipedia	CD27 (Hs)

Natural/Endogenous Ligands
CD70 {Sp: Human}

Adaptor proteins (Human)

TRAF2, SIVA

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference CD70 {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

CD27 (TNFRSF7) is a co-stimulatory immune checkpoint molecule that is expressed on various immune cells, including T cells and NK (natural killer) cells. The endogenous ligand for CD27 is CD70. CD27 interacts with various TRAF adaptor proteins and apoptosis regulatory protein SIVA (SIVA1). It has been recognized as playing an important role in priming, enhancing and sustaining a productive anti-cancer (CD8 T cell) adaptive immune response. CD27 is an immuno-oncology target [1-2]. The agonistic CD27 antibody varlilumab (CDX-1127) is being evaluated for efficacy against solid cancers and lymphomas in early phase clinical trials. Click here to link to ClinicalTrials.gov's list of registered varlilumab trials.

Immuno Process Associations

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  Chemotaxis & migration