Quaternary Structure: Complexes

Growth/differentiation factor receptors

Activin receptors

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	493	2q24.1	ACVR1C	activin A receptor type 1C
Mouse	1	493	2 C1.1	Acvr1c	activin A receptor, type IC
Rat	1	493	3q21	Acvr1c	activin A receptor type 1C

Previous and Unofficial Names

activin A receptor | activin A receptor type IC | activin receptor-like kinase 7 | ACTR-IC | ACVRLK7 | Alk7 | TGF-beta type 1 receptor

Database Links
Alphafold	Q8NER5 (Hs), Q8K348 (Mm), P70539 (Rn)
BRENDA	2.7.11.30
ChEMBL Target	CHEMBL5642 (Hs)
Ensembl Gene	ENSG00000123612 (Hs), ENSMUSG00000026834 (Mm), ENSRNOG00000004828 (Rn)
Entrez Gene	130399 (Hs), 269275 (Mm), 245921 (Rn)
Human Protein Atlas	ENSG00000123612 (Hs)
KEGG Enzyme	2.7.11.30
KEGG Gene	hsa:130399 (Hs), mmu:269275 (Mm), rno:245921 (Rn)
OMIM	608981 (Hs)
Pharos	Q8NER5 (Hs)
RefSeq Nucleotide	NM_001111031 (Hs), NM_001111030 (Mm), NM_139090 (Rn)
RefSeq Protein	NP_001104501 (Hs), NP_001028541 (Mm), NP_001104500 (Mm), NP_620790 (Rn)
UniProtKB	Q8NER5 (Hs), Q8K348 (Mm), P70539 (Rn)
Wikipedia	ACVR1C (Hs)

Enzyme Reaction
EC Number: 2.7.11.30

Natural/Endogenous Ligands
growth/differentiation factor-11 {Sp: Human}

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference SB-431542 Hs Inhibition - - 1-2 ⤷ [1-2]
Inhibitor Comments
ACVR1C (ALK7) activity is inhibited by 99% in the presence of 2.5μM SB-431542 [2]. Alternatively 8.9% inhibition is reported using 0.1μM compound and 54% inhibition at 1μM [1].