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activin A receptor type 1C

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Target id: 1790

Nomenclature: activin A receptor type 1C

Abbreviated Name: ALK7

Family: Type I receptor serine/threonine kinases

Quaternary Structure: Complexes
Growth/differentiation factor receptors
Activin receptors
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 493 2q24.1 ACVR1C activin A receptor type 1C
Mouse 1 493 2 C1.1 Acvr1c activin A receptor, type IC
Rat 1 493 3q21 Acvr1c activin A receptor type 1C
Previous and Unofficial Names Click here for help
activin A receptor | activin A receptor type IC | activin receptor-like kinase 7 | ACTR-IC | ACVRLK7 | Alk7 | TGF-beta type 1 receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Natural/Endogenous Ligands Click here for help
growth/differentiation factor-11 {Sp: Human}

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SB-431542 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - - 1-2
Inhibitor Comments
ACVR1C (ALK7) activity is inhibited by 99% in the presence of 2.5μM SB-431542 [2]. Alternatively 8.9% inhibition is reported using 0.1μM compound and 54% inhibition at 1μM [1].


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1. Li X, Wang L, Long L, Xiao J, Hu Y, Li S. (2009) Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5). Bioorg Med Chem Lett, 19 (16): 4868-72. [PMID:19616940]

2. Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. (2012) Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J Med Chem, 55 (22): 9946-57. [PMID:23130626]

How to cite this page

Type I receptor serine/threonine kinases: activin A receptor type 1C. Last modified on 30/03/2016. Accessed on 13/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,