Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	892	11p15.5	NLRP6	NLR family pyrin domain containing 6
Mouse	-	869	7 F5	Nlrp6	NLR family, pyrin domain containing 6
Rat	-	881	1q41	Nlrp6	NLR family, pyrin domain containing 6

Previous and Unofficial Names

CLR11.4 | NALP6 | PAN3 | NACHT, leucine rich repeat and PYD containing 6 | dual angiotensin II/vasopressin receptor | NLR family, pyrin domain containing 6 | PYPAF5 | AVR | NAVR | NAVR/AVR | NLR family

Database Links
Alphafold	P59044 (Hs), Q91WS2 (Mm), Q63035 (Rn)
Ensembl Gene	ENSG00000174885 (Hs), ENSMUSG00000038745 (Mm), ENSRNOG00000045677 (Rn)
Entrez Gene	171389 (Hs), 101613 (Mm), 171390 (Rn)
Human Protein Atlas	ENSG00000174885 (Hs)
KEGG Gene	hsa:171389 (Hs), mmu:101613 (Mm), rno:171390 (Rn)
OMIM	609650 (Hs)
Pharos	P59044 (Hs)
UniProtKB	P59044 (Hs), Q91WS2 (Mm), Q63035 (Rn)
Wikipedia	NLRP6 (Hs)

Immunopharmacology Comments

NLRP6 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 8 GO processes GO:0002526 acute inflammatory response IBA GO:0038187 pattern recognition receptor activity IDA GO:0050727 regulation of inflammatory response ISS GO:0050729 positive regulation of inflammatory response IDA GO:0140374 antiviral innate immune response IDA click arrow to show/hide IEA associations GO:0002438 acute inflammatory response to antigenic stimulus IEA GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA GO:0034122 negative regulation of toll-like receptor signaling pathway IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0050727 regulation of inflammatory response ISS GO:0050729 positive regulation of inflammatory response IDA click arrow to show/hide IEA associations GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA GO:0034122 negative regulation of toll-like receptor signaling pathway IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0034122 negative regulation of toll-like receptor signaling pathway IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:2000494 positive regulation of interleukin-18-mediated signaling pathway IDA click arrow to show/hide IEA associations GO:0032689 negative regulation of type II interferon production IEA

Immuno Process:  Tissue repair GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0042060 wound healing IEA

Physiological Functions Comments

Involved in negative regulation of inflammasome signalling, regulation of mucus secretion and host intestinal microbiota composition.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Colitis
Disease:  Colorectal cancer Disease Ontology: DOID:9256 OMIM: 114500
Disease:  Fatty liver disease, nonalcoholic, susceptibility to, 1; NAFLD1 OMIM: 613282 Role:  NLRP6 negatively regulates the progression of non-alcoholic fatty liver disease and mtabolic syndrome via modulation of gut bacteria. References:  1