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Target id: 1773

Nomenclature: NLRP6

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 892 11p15.5 NLRP6 NLR family pyrin domain containing 6
Mouse - 869 7 F5 Nlrp6 NLR family, pyrin domain containing 6
Rat - 881 1q41 Nlrp6 NLR family, pyrin domain containing 6
Previous and Unofficial Names Click here for help
CLR11.4 | NALP6 | PAN3 | NACHT, leucine rich repeat and PYD containing 6 | dual angiotensin II/vasopressin receptor | NLR family, pyrin domain containing 6 | PYPAF5 | AVR | NAVR | NAVR/AVR | NLR family
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
NLRP6 is an intracellular pattern recognition receptor (PRR). It is a member of the NACHT, LRR and PYD domains-containing protein (NALP) subfamily of PRRs. The presence of NALPs in inflammasomes underlies their involvement in regulating proinflammatory caspases (esp. caspase 1) and NF-κB.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Physiological Functions Comments
Involved in negative regulation of inflammasome signalling, regulation of mucus secretion and host intestinal microbiota composition.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Colitis
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Fatty liver disease, nonalcoholic, susceptibility to, 1; NAFLD1
OMIM: 613282
References:  1


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1. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ et al.. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 482 (7384): 179-85. [PMID:22297845]


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