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Carboxypeptidase B2 (plasma)

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Target id: 1594

Nomenclature: Carboxypeptidase B2 (plasma)

Family: M14: Carboxypeptidase A

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 423 13q14.13 CPB2 carboxypeptidase B2
Mouse - 422 14 D3 Cpb2 carboxypeptidase B2 (plasma)
Rat - 422 15q11 Cpb2 carboxypeptidase B2
Previous and Unofficial Names Click here for help
CPU | PCPB | TAFI | carboxypeptidase B2 (plasma, carboxypeptidase U) | carboxypeptidase R | thrombin-activatable fibrinolysis inhibitor | CPR | carboxypeptidase B2 (plasma)
Database Links Click here for help
Specialist databases
MEROPS M14.009 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.17.20

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4 [PMID: 19954973] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 pKi 3
pKi 8.5 (Ki 3.5x10-9 M) [3]
SQ-24,798 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pKi 2
pKi 8.4 (Ki 4x10-9 M) [2]
UK-396,082 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1x10-8 M) [2]
compound 3 [PMID: 14640538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0030449 regulation of complement activation TAS

References

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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem, 50 (24): 6095-103. [PMID:17990866]

3. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett, 20 (1): 92-6. [PMID:19954973]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase B2 (plasma). Last modified on 29/07/2015. Accessed on 26/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1594.