Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	674	Xq26.1	XPNPEP2	X-prolyl aminopeptidase 2
Mouse	-	674	X A3.2	Xpnpep2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Rat	-	674	Xq36	Xpnpep2	X-prolyl aminopeptidase 2

Previous and Unofficial Names

Aminopeptidase P 2 | membrane-bound X-prolyl aminopeptidase | mAPP | X-prolyl aminopeptidase (aminopeptidase P) 2

Database Links
Specialist databases
MEROPS	M24.005 (Hs)
Other databases
Alphafold	O43895 (Hs), Q99MA2 (Rn)
BRENDA	3.4.11.9
CATH/Gene3D	3.40.350.10
ChEMBL Target	CHEMBL4610 (Hs), CHEMBL2970 (Rn)
Ensembl Gene	ENSG00000122121 (Hs), ENSMUSG00000037005 (Mm), ENSRNOG00000004009 (Rn)
Entrez Gene	7512 (Hs), 170745 (Mm), 117522 (Rn)
Human Protein Atlas	ENSG00000122121 (Hs)
KEGG Enzyme	3.4.11.9
KEGG Gene	hsa:7512 (Hs), mmu:170745 (Mm), rno:117522 (Rn)
OMIM	300145 (Hs)
Orphanet	ORPHA281864 (Hs)
Pharos	O43895 (Hs)
RefSeq Nucleotide	NM_003399 (Hs), NM_133213 (Mm), NM_057155 (Rn)
RefSeq Protein	NP_003390 (Hs), NP_573476 (Mm), NP_476496 (Rn)
UniProtKB	O43895 (Hs), Q99MA2 (Rn)
Wikipedia	XPNPEP2 (Hs)

Enzyme Reaction
EC Number: 3.4.11.9

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference apstatin Hs Inhibition 6.2 pKi 1 ⤷ pKi 6.2 (Ki 6.4x10-7 M) [1] compound 6 [PMID: 10395480] Hs Inhibition 6.6 pIC50 1 ⤷ pIC50 6.6 (IC50 2.3x10-7 M) [1] apstatin Hs Inhibition 5.5 pIC50 1 ⤷ pIC50 5.5 (IC50 2.9x10-6 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Angioedema induced by ACE inhibitors, susceptibility to; AEACEI Synonyms: Renin-angiotensin-aldosterone system-blocker-induced angioedema [Orphanet: ORPHA100057] OMIM: 300909 Orphanet: ORPHA100057