Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 663 | 17p13.1 | ALOX12 | arachidonate 12-lipoxygenase, 12S type | |
| Mouse | - | 663 | 11 42.99 cM | Alox12 | arachidonate 12-lipoxygenase | |
| Rat | - | 663 | 10q24 | Alox12 | arachidonate 12-lipoxygenase, 12S type | |
| Previous and Unofficial Names |
| arachidonate 12-lipoxygenase, 12S-type | platelet-type lipoxygenase 12 | arachidonate 12-lipoxygenase, 12S type |
| Database Links |
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| Alphafold | P18054 (Hs), P39655 (Mm), F1LQ70 (Rn) |
| BRENDA | 1.13.11.31 |
| CATH/Gene3D | 2.60.60.20 |
| ChEMBL Target | CHEMBL3687 (Hs), CHEMBL3225 (Mm) |
| Ensembl Gene | ENSG00000108839 (Hs), ENSMUSG00000000320 (Mm), ENSRNOG00000027037 (Rn) |
| Entrez Gene | 239 (Hs), 11684 (Mm), 287454 (Rn) |
| Human Protein Atlas | ENSG00000108839 (Hs) |
| KEGG Enzyme | 1.13.11.31 |
| KEGG Gene | hsa:239 (Hs), mmu:11684 (Mm), rno:287454 (Rn) |
| OMIM | 152391 (Hs) |
| Pharos | P18054 (Hs) |
| UniProtKB | P18054 (Hs), P39655 (Mm), F1LQ70 (Rn) |
| Wikipedia | ALOX12 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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References
1. Luci DK, Jameson 2nd JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J et al.. (2014) Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem, 57 (2): 495-506. [PMID:24393039]
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