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HPGD

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Target id: 1384

Nomenclature: HPGD

Family: Prostaglandin synthases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 266 4q34.1 HPGD 15-hydroxyprostaglandin dehydrogenase
Mouse - 269 8 B2 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD)
Rat - 266 16p11 Hpgd 15-hydroxyprostaglandin dehydrogenase
Previous and Unofficial Names Click here for help
15-hydroxyprostaglandin dehydrogenase (NAD)  | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 15-PGDH | PGDH | prostaglandin dehydrogenase 1 | hydroxyprostaglandin dehydrogenase 15-(NAD) | hydroxyprostaglandin dehydrogenase 15 (NAD)
Database Links Click here for help
Alphafold P15428 (Hs), Q8VCC1 (Mm), O08699 (Rn)
BRENDA 1.1.1.141
ChEMBL Target CHEMBL1293255 (Hs)
Ensembl Gene ENSG00000164120 (Hs), ENSMUSG00000031613 (Mm), ENSRNOG00000010610 (Rn)
Entrez Gene 3248 (Hs), 15446 (Mm), 79242 (Rn)
Human Protein Atlas ENSG00000164120 (Hs)
KEGG Enzyme 1.1.1.141
KEGG Gene hsa:3248 (Hs), mmu:15446 (Mm), rno:79242 (Rn)
OMIM 601688 (Hs)
Pharos P15428 (Hs)
UniProtKB P15428 (Hs), Q8VCC1 (Mm), O08699 (Rn)
Wikipedia HPGD (Hs)
Enzyme Reaction Click here for help
EC Number: 1.1.1.141
Description Reaction Reference
15-hydroxyprostaglandins => 15-ketoprostaglandins
LXA4 => 15-keto-lipoxin A4 1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand
Sp.
Action
Value
Parameter
Reference
compound 3 [PMID: 21650226] Small molecule or natural product Hs Inhibition 8.1 pIC50 2
⤷ pIC50 8.1 (IC50 8x10-9 M) [2]

References

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1. Maddox JF, Serhan CN. (1996) Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J Exp Med, 183 (1): 137-46. [PMID:8551217]

2. Wu Y, Karna S, Choi CH, Tong M, Tai HH, Na DH, Jang CH, Cho H. (2011) Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors. J Med Chem, 54 (14): 5260-4. [PMID:21650226]

Contributors

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How to cite this page

Izzo AA, Mitchell JA. Eicosanoid turnover in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F243/2025.1.