CYP1, 2 and 3 family enzymes are involved in the biotransformation of xenobiotics, including clinically used drugs. Polymorphisms, particularly in the CYP2 family, impact upon an individual's response to drugs [31], including the risk of adverse drug reactions, drug efficacy and dose requirement.

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Kathryn Burns Department of Pharmacology and Clinical Pharmacology University of Auckland Auckland, New Zealand Nuala Ann Helsby Department of Molecular Medicine and Pathology University of Auckland Auckland, New Zealand