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Organic anion transporter 4

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Target id: 1030

Nomenclature: Organic anion transporter 4

Systematic Nomenclature: SLC22A11

Family: Organic anion transporters (OATs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 550 11q13.1 SLC22A11 solute carrier family 22 member 11
Previous and Unofficial Names Click here for help
OAT4 | solute carrier family 22 (organic anion/urate transporter), member 11
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC22A11 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
dehydroepiandrosterone sulphate Hs - 1
ochratoxin A Hs - - 1
uric acid Hs - - 2
estrone-3-sulphate Hs - 1
Stoichiometry Click here for help

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cephalothin Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.7 pKi 3
pKi 6.7 (Ki 2x10-7 M) [3]


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1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem, 275 (6): 4507-12. [PMID:10660625]

2. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens, 27 (4): 305-313. [PMID:29847376]

3. Takeda M, Babu E, Narikawa S, Endou H. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol, 438 (3): 137-42. [PMID:11909604]


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