Rhodopsin

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Target id: 2963

Nomenclature: Rhodopsin

Family: Opsin receptors

Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	348	3q22.1	RHO	rhodopsin
Mouse	7	348	6 53.72 cM	Rho	rhodopsin
Rat	7	348	4q42	Rho	rhodopsin

Database Links
Specialist databases
GPCRdb	OPSD_HUMAN (Hs), OPSD_MOUSE (Mm), OPSD_RAT (Rn)
Other databases
Alphafold	P08100 (Hs), P15409 (Mm), P51489 (Rn)
ChEMBL Target	CHEMBL4296308 (Hs)
Ensembl Gene	ENSG00000163914 (Hs), ENSMUSG00000030324 (Mm), ENSRNOG00000011144 (Rn)
Entrez Gene	6010 (Hs), 212541 (Mm), 24717 (Rn)
Human Protein Atlas	ENSG00000163914 (Hs)
KEGG Gene	hsa:6010 (Hs), mmu:212541 (Mm), rno:24717 (Rn)
OMIM	180380 (Hs)
Orphanet	ORPHA118315 (Hs)
Pharos	P08100 (Hs)
RefSeq Nucleotide	NM_000539 (Hs), NM_145383 (Mm), NM_033441 (Rn)
RefSeq Protein	NP_000530 (Hs), NP_663358 (Mm), NP_254276 (Rn)
UniProtKB	P08100 (Hs), P15409 (Mm), P51489 (Rn)
Wikipedia	RHO (Hs)

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Allele	Composition & genetic background	Accession	Phenotype Id	Phenotype	Reference
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0005551	abnormal eye electrophysiology	PMID: 15161873
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0006068	abnormal horizontal cell morphology	PMID: 15161873
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0006069	abnormal retinal neuronal layer morphology	PMID: 15161873
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0006074	abnormal retinal rod bipolar cell morphology	PMID: 15161873
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0001005	abnormal retinal rod cell morphology	PMID: 15161873
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0001327	decreased retinal photoreceptor cell number	PMID: 15161873
Cnga3^tm1Biel\|Rho^tm1Phm	Cnga3^tm1Biel/Cnga3^tm1Biel,Rho^tm1Phm/Rho^tm1Phm involves: C57BL/6	MGI:1341818 MGI:97914	MP:0008450	retinal photoreceptor degeneration	PMID: 15161873

Opsin receptors: Rhodopsin. Last modified on 15/07/2019. Accessed on 04/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2963.