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OPN5

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Target id: 161

Nomenclature: OPN5

Family: Opsin receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 354 6p12.3 OPN5 opsin 5 1,7
Mouse 7 377 17 B3 Opn5 opsin 5 1,7
Rat 6 534 9q13 Opn5 opsin 5
Previous and Unofficial Names Click here for help
opsin 5 | transmembrane protein 13 | GPR136 | PGR12 | neuropsin | PGR14 | TMEM13 | G protein-coupled receptor 136
Database Links Click here for help
Specialist databases
GPCRdb opn5_human (Hs), opn5_mouse (Mm), q7tqn6_rat (Rn)
Other databases
Alphafold Q6U736 (Hs), Q6VZZ7 (Mm), Q7TQN6 (Rn)
ChEMBL Target CHEMBL4523878 (Hs)
Ensembl Gene ENSG00000124818 (Hs), ENSMUSG00000043972 (Mm), ENSRNOG00000012689 (Rn)
Entrez Gene 221391 (Hs), 353344 (Mm), 316259 (Rn)
Human Protein Atlas ENSG00000124818 (Hs)
KEGG Gene hsa:221391 (Hs), mmu:353344 (Mm), rno:316259 (Rn)
OMIM 609042 (Hs)
Pharos Q6U736 (Hs)
RefSeq Nucleotide NM_181744 (Hs), NM_181753 (Mm), NM_181772 (Rn)
RefSeq Protein NP_859528 (Hs), NP_861418 (Mm), NP_861437 (Rn)
UniProtKB Q6U736 (Hs), Q6VZZ7 (Mm), Q7TQN6 (Rn)
Wikipedia OPN5 (Hs)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family
Comments:  Evidence indicates OPN5 triggers a UV-sensitive Gi-mediated signalling pathway in mammalian tissues [4].
References:  4
Tissue Distribution Click here for help
Retina, brain, testis
Species:  Human
Technique:  RT-PCR
References:  7
Eye, brain, testis
Species:  Mouse
Technique:  RT-PCR
References:  7
Retina (non-rod non-cone retinal neurons), brain, outer ears (epidermal and muscle cells)
Species:  Mouse
Technique:  Immunohistochemistry
References:  4
Retina (inner plexiform layer, inner nuclear layer)
Species:  Rat
Technique:  Immunohistochemistry
References:  6
Tissue Distribution Comments
The human Müller cell line MIO-M1 expresses OPN5 [2].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Clinically-Relevant Mutations and Pathophysiology Comments
Association studies suggested that genetic variation of OPN5 may contribute to the molecular mechanisms of bipolar disorder, and some aspects of memory and intelligence [3].
General Comments
OPN5 has been identified as a deep brain photoreceptor in birds [5]. Human and mouse OPN5 have a maximum UV absorption at 380nm, indicating that the receptor is the first human opsin with a peak sensitivity in the UV region [4].

References

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1. Fornai F, Lenzi P, Gesi M, Ferrucci M, Lazzeri G, Busceti CL, Ruffoli R, Soldani P, Ruggieri S, Alessandri MG et al.. (2003) Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition. J Neurosci, 23 (26): 8955-66. [PMID:14523098]

2. Hollborn M, Ulbricht E, Rillich K, Dukic-Stefanovic S, Wurm A, Wagner L, Reichenbach A, Wiedemann P, Limb GA, Bringmann A et al.. (2011) The human Müller cell line MIO-M1 expresses opsins. Mol Vis, 17: 2738-50. [PMID:22065927]

3. Izumi A, Iijima Y, Noguchi H, Numakawa T, Okada T, Hori H, Kato T, Tatsumi M, Kosuga A, Kamijima K et al.. (2008) Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Neuropsychopharmacology, 33 (13): 3237-45. [PMID:18354391]

4. Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y. (2011) UV-sensitive photoreceptor protein OPN5 in humans and mice. PLoS ONE, 6 (10): e26388. [PMID:22043319]

5. Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T. (2010) A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds. Proc Natl Acad Sci USA, 107 (34): 15264-8. [PMID:20679218]

6. Nieto PS, Valdez DJ, Acosta-Rodríguez VA, Guido ME. (2011) Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina. PLoS ONE, 6 (10): e26417. [PMID:22022612]

7. Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ. (2003) Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. FEBS Lett, 554 (3): 410-6. [PMID:14623103]

How to cite this page

Opsin receptors: OPN5. Last modified on 26/03/2021. Accessed on 25/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=161.