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ACKR2

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Target id: 314

Nomenclature: ACKR2

Family: Chemokine receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 384 3p22.1 ACKR2 atypical chemokine receptor 2
Mouse 7 378 9 F4 Ackr2 atypical chemokine receptor 2
Rat 7 382 8q32 Ackr2 atypical chemokine receptor 2
Previous and Unofficial Names Click here for help
CCR10 | CCR9 | CMBRK9 | C-C chemokine receptor D6 | chemokine binding protein 2 | CMKBR9
Database Links Click here for help
Specialist databases
GPCRdb ackr2_human (Hs), ackr2_mouse (Mm), ackr2_rat (Rn)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Endogenous agonists (Human)
CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626)
Immunopharmacology Comments
ACKR2 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0005044 scavenger receptor activity IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0004950 chemokine receptor activity IDA
GO:0016493 C-C chemokine receptor activity IBA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0004950 chemokine receptor activity IDA
GO:0016493 C-C chemokine receptor activity IBA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0006954 inflammatory response IEA
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

Created with Highcharts 10.3.3Log average relativeabundanceChart context menuLog average relative transcript abundance for Ackr2 in mouse tissuesOlfactory epitheliumBrainstemCerebellumCerebral cortexHippocampusHypothalamusOlfactory bulbPituitary glandStriatumRetinaWhole eyeAdrenal glandIsletThyroid/ParathyroidAortaVena cavaHeart atriumHeart ventricleLungTracheaBrown adiposeKidneyLiverSkeletal muscleWhite adiposeAdipocyteTongueEsophagusGall bladderLarge intestinePancreasSmall intestineStomachUrinary bladderSpleenThymusBone marrowOvaryTestesUterusSkin012Highcharts.com
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele
Composition & genetic background
Accession
Phenotype Id
Phenotype
Reference
Ccbp2tm1Gjg Ccbp2tm1Gjg/Ccbp2tm1Gjg
involves: 129/Sv * C57BL/6
MGI:1891697  MP:0001194 dermatitis PMID: 15750596 
Ccbp2tm1Gjg Ccbp2tm1Gjg/Ccbp2tm1Gjg
involves: 129/Sv * C57BL/6
MGI:1891697  MP:0001846 increased inflammatory response PMID: 15789340 

Contributors

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How to cite this page

Bachelerie F, Ben-Baruch A, Burkhardt AM, Charo IF, Combadiere C, Farber JM, Förster R, Graham GJ, Hills R, Horuk R, Locati M, Luster AD, Mantovani A, Matsushima K, Monaghan AE, Moschovakis GL, Murphy PM, Nibbs RJB, Nomiyama H, Oppenheim JJ, Power CA, Proudfoot  AEI, Rosenkilde MM, Rot A, Sozzani S, Sparre-Ulrich AH, Thelen M, Uddin M, Yoshie O, Zlotnik A. Chemokine receptors in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F14/2025.1.