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Contents:
Gene and Protein Information  |
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| class A G protein-coupled receptor: pseudogene in man | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | - | 2q14.1 | HTR5BP | 5-hydroxytryptamine receptor 5B, pseudogene | |
| Mouse | 7 | 370 | 1 52.98 cM | Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | |
| Rat | 7 | 370 | 13p12 | Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | |
| Gene and Protein Information Comments | ||||||
| The human orthologue of the mouse 5-ht5b receptor is non-functional due to interruption of the gene by stop codons. | ||||||
| Previous and Unofficial Names |
| GPR134 | HTR5B | G protein-coupled receptor 134 | 5Ht5b | MR22 | serotonin receptor 5B | 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene |
| Database Links |
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| Specialist databases | |
| GPCRdb | 5ht5b_mouse (Mm), 5ht5b_rat (Rn) |
| Other databases | |
| Alphafold | P31387 (Mm), P35365 (Rn) |
| ChEMBL Target | CHEMBL2619 (Rn) |
| Ensembl Gene | ENSG00000125631 (Hs), ENSMUSG00000050534 (Mm), ENSRNOG00000002549 (Rn) |
| Entrez Gene | 645694 (Hs), 15564 (Mm), 79247 (Rn) |
| Human Protein Atlas | ENSG00000125631 (Hs) |
| KEGG Gene | hsa:645694 (Hs), mmu:15564 (Mm), rno:79247 (Rn) |
| RefSeq Nucleotide | NG_008325 (Hs), NM_010483 (Mm), NM_024395 (Rn) |
| RefSeq Protein | NP_077371 (Rn) |
| UniProtKB | P31387 (Mm), P35365 (Rn) |
| Wikipedia | HTR5BP (Hs) |
| Natural/Endogenous Ligands |
| 5-hydroxytryptamine |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
1. Matthes H, Boschert U, Amlaiky N, Grailhe R, Plassat JL, Muscatelli F, Mattei MG, Hen R. (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol, 43 (3): 313-9. [PMID:8450829]
2. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998) Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci, 861: 85-90. [PMID:9928243]
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