DX-2507 
GtoPdb Ligand ID: 9959
Compound class:
Antibody
Comment: DX-2507 is a fully human anti-FcRn monoclonal antibody [2] that was originally developed by Dyax Corporation, and is being progressed by Shire following their acquisition of Dyax.
A X-ray crystal structure of DX-2507-Fab in complex with FcRn has been published [1]. The Protein Data Bank identifier for the 2.15Å structure of unbound DX-2507-Fab is 5WHJ. 
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| Bioactivity Comments |
| DX-2507 binds IgG throughout the endocytic/exocytosis cycle both in the endosome at acidic pH and at the cell surface at neutral pH [2]. It depletes IgG in monkeys by >60% following two subcutaneous injections [2]. DX-2507 does not disrupt serum albumin binding to FcRn. It does not induce hypogammaglobulinemia and has no effect on other classes of antibodies. Nor does DX-2507 disrupt the primary response to novel antigen. All indications are that DX-2507-mediated FcRn antagonism has little implication with regards to general immune system disruption or infection risk. |
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