fontolizumab

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fontolizumab

GtoPdb Ligand ID: 9847

Synonyms: HuZAF

Compound class: Antibody

Comment: Fontolizumab (HuZAF) is a humanized anti-IFNγ mAb designed for the treatment of auto-immune diseases like Crohn's disease. This antibody is claimed in patent US6329511 [4]. It is one of the novel agents for immune-mediated inflammatory diseases discussed in Baker et al. (2018) [1].

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Fontolizumab achieves its immunosuppressive activity via neutralisation of circulating IFNγ [4].

Immunopharmacology Comments

Fontolizumab achieves its immunosuppressive activity via neutralisation of circulating IFNγ [4].

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Crohn's disease	Disease Ontology: DOID:8778 OMIM: 266600 Orphanet: ORPHA206	Fontolizumab has completed Phase 2 clinical trial in patients with moderate to severe Crohn's disease- see NCT00072943	2-3