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lusvertikimab   Click here for help

GtoPdb Ligand ID: 9604

Synonyms: Effi-7 | MD-707 | OSE-127 | OSE127
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lusvertikimab (OSE-127) is a humanized monoclonal antibody that targets the alpha chain of the interleukin 7 receptor (CD127; IL7R). It antagonises IL-7R signalling by T effector cells, thus down regulating their contribution to the immune response. It was proposed to treat autoimmune diseases, transplant rejection and as an immuno-oncology candidate [2,5]. It is likely one of the candidates claimed in patent WO2015189302 [4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E et al.. (2018)
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.
Nat Commun, 9 (1): 4483. [PMID:30367166]
2. Lenk L, Baccelli I, Laqua A, Heymann J, Reimer C, Dietterle A, Winterberg D, Mary C, Corallo F, Taurelle J et al.. (2024)
The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis.
Blood, 143 (26): 2735-2748. [PMID:38518105]
3. Poirier N, Baccelli I, Belarif L, Abès R, Teppaz G, Mary C, Poli S, Fromond C, Girault I, Pengam S et al.. (2023)
First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα.
J Immunol, 210 (6): 753-763. [PMID:36734626]
4. Poirier N, Mary C, Vanhove B. (2015)
Antibodies directed against CD127.
Patent number: WO2015189302. Assignee: Effimune. Priority date: 10/06/2014. Publication date: 17/12/2015.
5. Rivière E, Pascaud J, Virone A, Dupré A, Ly B, Paoletti A, Seror R, Tchitchek N, Mingueneau M, Smith N et al.. (2021)
Interleukin-7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren's Syndrome.
Arthritis Rheumatol, 73 (4): 631-640. [PMID:33058491]
6. Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, Okamoto R, Oshima S, Nakamura T, Kanai T, Uehira M et al.. (2003)
Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis.
J Immunol, 171 (3): 1556-63. [PMID:12874249]