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lusvertikimab   Click here for help

GtoPdb Ligand ID: 9604

Synonyms: Effi-7 | MD-707 | OSE-127 | OSE127
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lusvertikimab (OSE-127) is a humanized monoclonal antibody that targets the alpha chain of the interleukin 7 receptor (CD127; IL7R). It antagonises IL-7R signalling by T effector cells, thus down regulating their contribution to the immune response. It was proposed to treat autoimmune diseases, transplant rejection and as an immuno-oncology candidate [2,5]. It is likely one of the candidates claimed in patent WO2015189302 [4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
IL-7Rα is expressed on effector T (Teff) cells, but not on regulatory T (Treg) cells. IL- 7 is a cytokine which specifically regulates the tissue migration of human Teff cells, especially in the gut [6] and skin. Blocking this receptor prevents the migration of pathogenic Teff cells to the intestinal mucosa, but preserves Treg function, thereby retaining their positive impact in autoimmune diseases such as ulcerative colitis. Belarif et al. (2018) reported preclinical efficacy of antagonistic anti-IL-7Rα monocloncals in a non-human primate model of autoimmune chronic skin inflammation [1].