setrusumab   Click here for help

GtoPdb Ligand ID: 9202

Synonyms: BPS 804 | BPS804 | UX-143 | UX143
Compound class: Antibody
Comment: Setrusumab (BPS-804) is a fully human investigational monoclonal antibody targeting sclerostin (SOST; which is a negative regulator of bone formation), that is intended to improve bone density.
Development of anti-sclerostin antibodies by Novartis is claimed in patent WO2009047356 [2], although we cannot definitively conclude that BPS-804 is claimed within that patent application.
The potential of sclerostin as a therapeutic target in bone diseases is reviewed by Lewiecki (2014) [3].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
sclerostin Primary target of this compound Hs Antibody Binding - - -
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