lanadelumab   Click here for help

GtoPdb Ligand ID: 9094

Synonyms: DX-2930 | lanadelumab-flyo | Takhzyro® | X124-G01
Approved drug
lanadelumab is an approved drug (EMA & FDA (2018))
Compound class: Antibody
Comment: Lanadelumab is a fully human monoclonal antibody targeting the serine peptidase kallikrein B1 (KLKB1, a.k.a. plasma kallikrein). It is generated in recombinant Chinese hamster ovary cells.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Protein BLAST analysis reveals 100% matches with peptides claimed in patent US8816055 [5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
Patent US8816055 [5] states that X124-G01 (DX-2930) is a germlined IgG produced in CHO cells, with the same variable heavy and light chains as isolate X115-F02, except with the C-terminal Lys removed. The affinity value in the table is for X115-F02, as no data is provided for X124-G01. The preferred antibody does not bind to prekallikrein [5].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kallikrein B1 Primary target of this compound Hs Antibody Binding 10.1 pIC50 - 5
⤷ pIC50 10.1 (IC50 9x10-11 M) [5]