difelikefalin   Click here for help

GtoPdb Ligand ID: 9044

Synonyms: CR845 | D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] | FE-202845 | Kapruvia® | Korsuva® | SEQ ID NO: 2 [6]
Approved drug Immunopharmacology Ligand
difelikefalin is an approved drug (FDA (2021), EMA (2022))
Compound class: Peptide
Comment: Difelikefalin is a first-in-class, peripherally acting, highly selective peptide agonist of the κ-opioid receptor, that was developed for potential to treat chronic itch [4] and it is claimed in patent US7402564B1 [6]. This patent provides extensive results from preclinical testing, assessing the analgesic and anti-pruritic potential of difelikefalin.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

difelikefalin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES NCCCCC(C(=O)N1CCC(CC1)(N)C(=O)O)NC(=O)C(NC(=O)C(NC(=O)C(Cc1ccccc1)N)Cc1ccccc1)CC(C)C
Isomeric SMILES NCCCC[C@H](C(=O)N1CCC(CC1)(N)C(=O)O)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)N)Cc1ccccc1)CC(C)C
InChI InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1
InChI Key FWMNVWWHGCHHJJ-SKKKGAJSSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Cowan A, Kehner GB, Inan S. (2015)
Targeting Itch with Ligands Selective for κ Opioid Receptors.
Handb Exp Pharmacol, 226: 291-314. [PMID:25861786]
2. Fishbane S, Jamal A, Munera C, Wen W, Menzaghi F, KALM-1 Trial Investigators. (2020)
A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus.
N Engl J Med, 382 (3): 222-232. [PMID:31702883]
3. Hercz D, Jiang SH, Webster AC. (2020)
Interventions for itch in people with advanced chronic kidney disease.
Cochrane Database Syst Rev, 12: CD011393. [PMID:33283264]
4. Janecka A, Perlikowska R, Gach K, Wyrebska A, Fichna J. (2010)
Development of opioid peptide analogs for pain relief.
Curr Pharm Des, 16 (9): 1126-35. [PMID:20030621]
5. Manenti L, Fenaroli P. (2022)
Difelikefalin for pruritus associated with renal disease.
Drugs Today (Barc), 58 (9): 427-435. [PMID:36102903]
6. Schteingart CD, Menzaghi F, Jiang G, Alexander RV, Sueiras-Diaz J, Spencer RH, Chalmers DT, Luo Z. (2008)
Synthetic peptide amides.
Patent number: US7402564 B1. Assignee: Cara Therapeutics, Inc.. Priority date: 10/11/2006. Publication date: 22/07/2008.