lenzilumab

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Ligands
lenzilumab

GtoPdb Ligand ID: 8935

Synonyms: KB-003 | KB003

Comment: Lenzilumab is a fully human IgG1κ moncolonal antibody targeting granulocyte-macrophage colony-stimulating factor (GM-CSF), being investigated for its immunomodulatory potential.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST peptide searches using the variable regions of the heavy and light chains of the antibody reveal exact matches with sequences submitted with patent US8075885 B2 [1].

No information available.

No information available.

Summary of Clinical Use
Lenzilumab has completed Phase 2 clinical trial for uncontrolled asthma, whereas a Phase 2 study in patients with inadequately controlled rheumatoid arthritis has been terminated. A Phase 1 trial in patients with previously treated chronic myelomonocytic leukemia (CMML) is ongoing [3]. SARS-CoV-2 and COVID-19:Lenzilumab has been entered into clinical trial to determine if blocking GM-CSF signalling can help to alleviate the immune-mediated cytokine release syndrome in patients with severe or critical COVID-19 pneumonia. The aim would be reduce the time to recovery in hospitalised patients.

Summary of Clinical Use

Lenzilumab has completed Phase 2 clinical trial for uncontrolled asthma, whereas a Phase 2 study in patients with inadequately controlled rheumatoid arthritis has been terminated. A Phase 1 trial in patients with previously treated chronic myelomonocytic leukemia (CMML) is ongoing [3].

SARS-CoV-2 and COVID-19:Lenzilumab has been entered into clinical trial to determine if blocking GM-CSF signalling can help to alleviate the immune-mediated cytokine release syndrome in patients with severe or critical COVID-19 pneumonia. The aim would be reduce the time to recovery in hospitalised patients.

Mechanism Of Action and Pharmacodynamic Effects
The antibody functionally neutralizes soluble GM-CSF. The potential clinical utility of anti-GM-CSF therapy is discussed in [2]. In CMML, cancer cells are hypersensitive to GM-CSF, with their cell growth and survival stimulated in the presence of very low levels of this cytokine. Using lenzilumab to neutralise GM-CSF in in vitro experiments kills CMML cells.

Mechanism Of Action and Pharmacodynamic Effects

The antibody functionally neutralizes soluble GM-CSF. The potential clinical utility of anti-GM-CSF therapy is discussed in [2].
In CMML, cancer cells are hypersensitive to GM-CSF, with their cell growth and survival stimulated in the presence of very low levels of this cytokine. Using lenzilumab to neutralise GM-CSF in in vitro experiments kills CMML cells.

Clinical Trials
Clinical Trial ID	Title	Type	Source	Comment	References
NCT04351152	Phase 3 Study to Evaluate Efficacy and Safety of Lenzilumab in Patients With COVID-19	Phase 3 Interventional	Humanigen, Inc.