tezepelumab   Click here for help

GtoPdb Ligand ID: 8933

Synonyms: AMG 157 | AMG-157 | MEDI-9929 | MEDI9929 | tezepelumab-ekko | Tezspire®
Approved drug Immunopharmacology Ligand
tezepelumab is an approved drug
Compound class: Antibody
Comment: Tezepelumab is a fully human IgG2λ monoclonal antibody, that is a potential first-in-class agent that blocks the epithelial-cell-derived cytokine thymic stromal lymphopoietin (TSLP- which is an upstream modulator of multiple inflammatory pathways). It is being investigated for its immunomodulatory action.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
thymic stromal lymphopoietin Primary target of this compound Hs Antibody Binding 10.5 – 10.8 pKd - 3
⤷ pKd 10.5 – 10.8 (Kd 2.92x10-11 – 1.58x10-11 M) [3]