ularitide

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Ligands
ularitide

GtoPdb Ligand ID: 8446

Synonyms: ESP-305

Comment: Ularitide is a synthetic 32 amino acid peptidomimetic of human urodilatin (atrial natriuretic peptide (95-126)).

Summary
Biological activity
Clinical data
References
Structure
Similar ligands

No information available.

No information available.

Summary of Clinical Use
Ularitide is being evaluated in Phase 3 clinical trial as a potential treatment for acute heart failure [1-2].

Summary of Clinical Use

Ularitide is being evaluated in Phase 3 clinical trial as a potential treatment for acute heart failure [1-2].

Mechanism Of Action and Pharmacodynamic Effects
Urodilatin is a kidney specific fragment of ANP. Urodilatin induces strong diuresis and natriuresis, being invloved in the regulation of body fluid volume and water-electrolyte excretion. Ularitide effectively mimics ANP's inhibitory action on the renin-angiotensin-aldosterone system which is activated early in the development of congestive heart failure (CHF) to stimulate water excretion via the kidneys [2].

Mechanism Of Action and Pharmacodynamic Effects

Urodilatin is a kidney specific fragment of ANP. Urodilatin induces strong diuresis and natriuresis, being invloved in the regulation of body fluid volume and water-electrolyte excretion. Ularitide effectively mimics ANP's inhibitory action on the renin-angiotensin-aldosterone system which is activated early in the development of congestive heart failure (CHF) to stimulate water excretion via the kidneys [2].