simtuzumab   Click here for help

GtoPdb Ligand ID: 8412

Synonyms: AB0024 | GS 6624 | GS-6624
Compound class: Antibody
Comment: Simtuzumab is an investigational monoclonal antibody targeting lysyl oxidase-like 2 (LOXL2). The antibody is reported to be an allosteric modulator of LOXL2 enzymatic activity [6-7].
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence matches reveal that US8461303 is the covering patent [7]. The heavy chain variable domain sequence of simtuzumab (from IMGT) matches the sequence for the AB0023 M20 variant 3 clone in US8461303.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
The Ki value in the table below is taken from Figure 10 as presented in US8461303 [7].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
lysyl oxidase like 2 Primary target of this compound Hs Inhibitor Inhibition 7.2 pKi - 7
⤷ pKi 7.2 (Ki 6.7x10-8 M) [7]