fresolimumab

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Ligands
fresolimumab

GtoPdb Ligand ID: 8264

Synonyms: GC1008 | PET1073G12 [1]

Comment: Fresolimumab is a monoclonal antibody targeting all isoforms of transforming growth factor beta (TGF-β1, -β2 and -β3.).
Annotated peptide sequence information for this antibody is available from its IMGT/mAb-DB link.
BLAST peptide sequence analysis reveals patent US7723486 as the covering document for fresolimumab [1].

Summary
Biological activity
Clinical data
References

Bioactivity Comments
In cellular proliferation assays fresolimumab (coded as PET1073G12) neutralises the proliferative effects of TGF-β1, TGF-β2 and TGF-β3 with IC₅₀ values of 0.44-0.8nM, 12-13nM and 2.8-6nM respectively [1]. Binding affinity values are not provided in the associated patent.

Bioactivity Comments

In cellular proliferation assays fresolimumab (coded as PET1073G12) neutralises the proliferative effects of TGF-β1, TGF-β2 and TGF-β3 with IC₅₀ values of 0.44-0.8nM, 12-13nM and 2.8-6nM respectively [1]. Binding affinity values are not provided in the associated patent.

Selectivity at ligand targets

Key to terms and symbols

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Target			Sp.	Type	Action	Value	Parameter	Concentration range (M)	Reference
TGFβ1			Hs	Antibody	Binding	-	-	-	1
⤷	[1]