sargramostim

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Ligands
sargramostim

GtoPdb Ligand ID: 7905

Synonyms: Leukine®

sargramostim is an approved drug (FDA (1991))

Comment: Sargramostim is recombinant human GM-CSF, produced in E.coli. Compared to the endogenous peptide sargramostim has a Arg>Leu substitution at residue 23.

Summary
Biological activity
Clinical data
References
Structure
Similar ligands

References
1. Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, Leming P, Puzanov I, Shin D, Kirkwood JM. (2014) Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA, 312 (17): 1744-53. [PMID:25369488]

References

1. Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, Leming P, Puzanov I, Shin D, Kirkwood JM. (2014)
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
JAMA, 312 (17): 1744-53. [PMID:25369488]