albiglutide   Click here for help

GtoPdb Ligand ID: 7386

Synonyms: Eperzan® | GSK716155 | Tanzeum®
Approved drug
albiglutide is an approved drug (FDA and EMA (2014))
Compound class: Peptide
Comment: Albiglutide is recombinant protein engineered by fusing the gene for glucagon-like peptide 1 (GLP-1; an incretin secreted in the gut) with the gene for human albumin. In this case the GLP-1 appears to contain an amino acid substitution (Ala to Glu at the C-terminal) directly adjacent to the dipeptidyl peptidase-4 (DPP-4; the enzyme responsible for in vivo degradation of GLP-1) hydrolysis site, which renders the peptide resistant to cleavage by this enzyme [3,5]. In conjunction with the fusion to albumin [2] this drug has an extended half-life compared to other approved drug GLP-1 mimetics.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Peptide
Approved drug? Yes. EMA (2014)  |  FDA (2014)
International Nonproprietary Names Click here for help
INN number INN
8829 albiglutide
Synonyms Click here for help
Eperzan® | GSK716155 | Tanzeum®
Database Links Click here for help
Specialist databases
GPCRdb Ligand albiglutide
IMGT/mAb-DB 397
Other databases
ChEMBL Ligand CHEMBL2107841
GtoPdb PubChem SID 178103958
Search PubMed clinical trials albiglutide
Search PubMed titles albiglutide
Search PubMed titles/abstracts albiglutide
Wikipedia Albiglutide