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mestranol   Click here for help

GtoPdb Ligand ID: 7087

Synonyms: EE3-ME
Approved drug
mestranol is an approved drug (FDA (1962))
Compound class: Metabolite
Comment: Mestranol is the inactive prodrug of ethinylestradiol. Marketing authorisation is for a combined norethisterone/mestranol formulation.
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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 29.46
Molecular weight 310.19
XLogP 4.57
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C#CC1(O)CCC2C1(C)CCC1C2CCc2c1ccc(c2)OC
Isomeric SMILES C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCc2c1ccc(c2)OC
InChI InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1
InChI Key IMSSROKUHAOUJS-MJCUULBUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Metabolite
Approved drug? Yes. US FDA (1962)
Is prodrug? Yes
Active form ethinylestradiol
IUPAC Name Click here for help
(8R,9S,13S,14S,17R)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
International Nonproprietary Names Click here for help
INN number INN
1139 mestranol
Synonyms Click here for help
EE3-ME
Database Links Click here for help
CAS Registry No. 72-33-3
ChEBI CHEBI:6784
ChEMBL Ligand CHEMBL1201151
DrugBank Ligand DB01357
DrugCentral Ligand 1714
GtoPdb PubChem SID 178103665
PubChem CID 6291
Search Google for chemical match using the InChIKey IMSSROKUHAOUJS-MJCUULBUSA-N
Search Google for chemicals with the same backbone IMSSROKUHAOUJS
Search PubMed clinical trials mestranol
Search PubMed titles mestranol
Search PubMed titles/abstracts mestranol
UniChem Compound Search for chemical match using the InChIKey IMSSROKUHAOUJS-MJCUULBUSA-N
UniChem Connectivity Search for chemical match using the InChIKey IMSSROKUHAOUJS-MJCUULBUSA-N
Wikipedia Mestranol

Product suppliers

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MedChemExpress
Mestranol (links to external site)
Cat. No. HY-B0390