denileukin diftitox   Click here for help

GtoPdb Ligand ID: 7044

Synonyms: DAB389 IL2 | denileukin diftitox-cxdl | LY 335348 | Lymphir® | Ontak®
Approved drug Immunopharmacology Ligand
denileukin diftitox is an approved drug (FDA (1999))
Compound class: Peptide
Comment: Denileukin diftitox is an anti-cancer immunotherapy drug that was designed to target and eradicate malignant (IL-2 receptor-expressing) T cells. It is a recombinant protein containing peptide sequences of both interleukin-2 and diphtheria toxin [1,5]. It simultaneously directly kills IL-2R expressing tumour cells and promotes depletion of host Treg cells which enhances the immune response
Immunopharmacology Disease
Disease X-Refs Comment References
Cutaneous T cell lymphoma Disease Ontology: DOID:0060061
 Approved drug for CTCL.