Summary of Clinical Use

Approved to treat systematic lupus erythematosus (SLE) [3-4]. The original formulation of belimumab was administered intravenously. In July 2017, a new self-injectable subcutaneous formulation of belimumab for the treatment of adult patients with active, autoantibody‑positive SLE was FDA approved, which allows self-administration of medication at home as an alternative to attending a medical facility to receive an i.v. infusion. Additional indications being evaluated with belimumab include vasculitis (Phase 3), and myaesthenia gravis and transplant rejection (both Phase 2).

Mechanism Of Action and Pharmacodynamic Effects

Suppresses B-cell mediated immunity and the autoimmune response by binding to circulating soluble TNFSF13B (BAFF; BLyS), effectively reducing the amount of TNFSF13B available to mediate B-cell activation [2,5].

External links

For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA)