belimumab   Click here for help

GtoPdb Ligand ID: 6887

Synonyms: Benlysta® | hBlySmAb-1.1 | LimphoStat-B | lymphostat-B
Approved drug Immunopharmacology Ligand
belimumab is an approved drug (FDA (2011), EMA (2011))
Compound class: Antibody
Comment: Belimumab is a monoclonal antibody targeting TNFSF13B (BAFF; BLyS) [1,5] , an immunostimulant essential for normal B cell maintenance and humoral immunity [6], and which is reported to be elevated in systemic lupus erythematosus (SLE) and other autoimmune diseases.
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Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
BAFF Primary target of this compound Hs Antibody Binding 10.6 pEC50 - 1
⤷ pEC50 10.6 (EC50 2.4x10-11 M) [1]
Description: Binding affinity to immobilised BLyS