pegaptanib

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Ligands
pegaptanib

GtoPdb Ligand ID: 6836

Synonyms: EYEOO1 | Macugen® | NX183 | pegaptanib sodium

pegaptanib is an approved drug (FDA (2004), EMA (2006))

Comment: Pegaptanib is a RNA oligonucleotide aptamer that acts as a vascular endothelial growth factor A antagonist, anti-angiogenic agent.
It is a 28-mer RNA oligonucleotide that is covalently linked to two branched 20-kD polyethylene glycol (PEG) chains. Pegaptanib binds to the 165 isoform of VEGFA. It is formulated as a sodium adduct.
The basic nucleotide sequence has modified nucleotides and a 5' pentylamino linker that acts as the PEG anchor.

References
1. Gragoudas ES, Adamis AP, Cunningham Jr ET, Feinsod M, Guyer DR, VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. (2004) Pegaptanib for neovascular age-related macular degeneration. N Engl J Med, 351 (27): 2805-16. [PMID:15625332]
2. Nimjee SM, Rusconi CP, Sullenger BA. (2005) Aptamers: an emerging class of therapeutics. Annu Rev Med, 56: 555-83. [PMID:15660527]

References

1. Gragoudas ES, Adamis AP, Cunningham Jr ET, Feinsod M, Guyer DR, VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. (2004)
Pegaptanib for neovascular age-related macular degeneration.
N Engl J Med, 351 (27): 2805-16. [PMID:15625332]

2. Nimjee SM, Rusconi CP, Sullenger BA. (2005)
Aptamers: an emerging class of therapeutics.
Annu Rev Med, 56: 555-83. [PMID:15660527]