pegaptanib   Click here for help

GtoPdb Ligand ID: 6836

Synonyms: EYEOO1 | Macugen® | NX183 | pegaptanib sodium
Approved drug
pegaptanib is an approved drug (FDA (2004), EMA (2006))
Compound class: Nucleic acid
Comment: Pegaptanib is a RNA oligonucleotide aptamer that acts as a vascular endothelial growth factor A antagonist, anti-angiogenic agent.
It is a 28-mer RNA oligonucleotide that is covalently linked to two branched 20-kD polyethylene glycol (PEG) chains. Pegaptanib binds to the 165 isoform of VEGFA. It is formulated as a sodium adduct.
The basic nucleotide sequence has modified nucleotides and a 5' pentylamino linker that acts as the PEG anchor.
No information available.
Summary of Clinical Use Click here for help
Used to treat neovascular (wet) age-related macular degeneration
Mechanism Of Action and Pharmacodynamic Effects Click here for help
A pegylated anti-VEGF nucleic acid aptamer which inhibits angiogenesis and blood vessel permeability when administered intraoccularly (into the vitreous humor)
External links Click here for help
For extended ADME data see the following:

Electronic Medicines Compendium (eMC)
Drugs.com
European Medicines Agency (EMA)