drotrecogin alfa

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Ligands
drotrecogin alfa

GtoPdb Ligand ID: 6788

Synonyms: drotrecogin alfa (activated) | HSDB 7366 | Xigris®

drotrecogin alfa is an approved drug (FDA (2001), EMA (2009))

Compound class: Peptide

Comment: Drotrecogin alfa (activated) is a recombinant form of human activated protein C.

Summary
Biological activity
Clinical data
References
Structure

References
1. Kanji S, Devlin JW, Piekos KA, Racine E. (2001) Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis. Pharmacotherapy, 21 (11): 1389-402. [PMID:11714212]
2. Kapur S, Kupfer Y, Tessler S. (2001) Recombinant human activated protein C for severe sepsis. N Engl J Med, 345 (3): 219-20; author reply 220-1. [PMID:11463021]

References

1. Kanji S, Devlin JW, Piekos KA, Racine E. (2001)
Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis.
Pharmacotherapy, 21 (11): 1389-402. [PMID:11714212]

2. Kapur S, Kupfer Y, Tessler S. (2001)
Recombinant human activated protein C for severe sepsis.
N Engl J Med, 345 (3): 219-20; author reply 220-1. [PMID:11463021]